Fig. 7. High-power transmission electron microscopy images of osteocytes. Electron micrographs show higher magnification of perilacunar matrix organization of osteocytes in (A) wild-type and (B) MT1-MMP-deficient 48-day-old mice. Canaliculi (can), fine osteocytic processes (p) and lacunae (Lac) are indicated. (A) Collagen fibrils have lost their banded pattern and granular staining in the lacuna wall. (B) The collagen fibrils display characteristic cross-striated banding pattern and no evidence of fine granular material. Lacunae and fine cellular processes are more obvious in the wild-type than in the deficient mouse. Bar, 1 µm.