Fig. 7. Calpain inhibition results in apical relocalization of basal bodies in foxj1^-/- trachea. (A,B) By transmission electron microscopy, basal bodies (arrowheads) are found to be apically localized in an E17.5 foxj1^+/+ tracheal explant (A), but distributed throughout the cytoplasm of foxj1^-/- tracheal explant (B); both cultured for 96 hours. (C) Treatment of cultured E17.5 foxj1^-/- tracheal explant with 10 mM calpain II inhibitor results in localization of basal bodies (arrowheads) to cell apex. Scale bars: 500 nm (A,B); 250 nm (C).