Fig. 2. Structure of a ß3 tail-talin F3 complex. The structure of the ß3 tail residues 738-748 (shown as sticks) bound to the talin PTB-like domain (PDB: 1MK7). Mutations at talin residues R358, W359 or A360 (shown in green) inhibit ß3 tail binding, whereas mutation of K357 (shown in orange) did not. Integrin residues L746 and W739, which selectively inhibit talin binding and integrin activation when mutated to alanine, are shown in red; Y747, which inhibits talin, filamin and Syk binding when mutated to alanine, is shown in yellow. This figure was first published as Supporting Online Material at Science online (Tadokoro et al., 2003).