Fig. 1. Cru1 belongs to the Fizzy-related family of APC activators. (A) The Cru1 protein. The seven WD repeats are shown, as well as the putative C-box (DRFIPQR). (B) Comparison of the predicted amino acid sequence encoded by the cru1 gene with the amino acid sequences of S. cerevisiae Hct1/Cdh1 and S. pombe Ste9/Srw1 proteins. Gray boxes indicate identity. Notice that homology between these proteins extends beyond the seven WD repeats. (C) Dendrogram of fungal APC activators. U. maydis Cru1 groups in the same branch as other Fizzy-related activators. Bar, 0.05 substitutions per aa.