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Fig. 4. Shugoshin protects centromeric Rec8 during meiosis I. At the onset of anaphase I, Sgo1 protects centromeric Rec8 from separase cleavage; centromeric cohesion is thereby preserved until meiosis II. At the onset of anaphase II, the residual Rec8 is cleaved, which results in the separation of sister chromatids. In sgo1{Delta} cells, all Rec8 is disrupted at meiosis I; therefore, sister chromatid cohesion is lost prior to meiosis II. This brings about random segregation in meiosis II.