Fig. 4. Partial inhibition of VEGF-C_NC-induced in vitro angiogenesis by blocking antibody to VEGFR-3. Confluent BAE cells monolayers on three-dimensional collagen gels were treated with VEGF-C_NC (100 ng/ml). Monoclonal anti-human VEGFR-3 antibody hF4-3C5 was added at the concentrations indicated. Invasion was measured after 4 days and is expressed as percent of sprouting induced by VEGF-C_NC alone. Results are shown as the means±s.d. of three wells.