Fig. 3. Potential role of annexin-A2–S100A10 in the transport of plasma membrane channels. Plasma membrane ion channels containing a binding site for S100A10 (e.g. the Ca²⁺ channel TRPV5 or the sodium channel Na_v 1.8) can be directed to the cell surface through a S100A10-mediated interaction with the annexin-A2–S100A10 complex and subsequent membrane binding of the annexin A2 subunits of the complex. This could occur within the biosynthetic pathway or upon recycling of the channels through an endosomal recycling organelle.