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Fig. 3. Distribution of Me(3)K20H4 in murine metaphase chromosomes. (A) DAPI profile of the chromosome-spread from a mouse C127 cell. (B) The spread in A labelled with anti-Me(3)K20H4, which shows labelling of peri-centromeric heterochromatin. The labelling is punctate, as seen in the inset, which is a magnified image of the centromeric Me(3)K20H4 staining indicated by the asterisk. (C) The spread in A labelled with anti-AcH4 antibody. (D) The merged image of B and C. Arrows in B,C and D point to the inactive X chromosome (Xi), which is underacetylated in C. Scale bar: 5 µm.