Fig. 5. Migration tracks of control and Endo N-treated OPCs. (A) Representative time-lapse sequences of OPC migration under control conditions and in the presence of Endo N. Arrows indicate the source of PDGF. It is evident that control cells maintain the directionality of migration towards the source of PDGF, whereas Endo N-treated cells make random turns. Asterisks indicate migrating cells. (B) The migration tracks of two representative control cells and two Endo N-treated cells in the presence of PDGF gradient, taking the starting point for each cell at the intersection between X and Y axes (0, 0) and the source of PDGF at the top. Bars, 30 µm.