JCS -- Lucas et al. 117 (1): 31 Figure IG1

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Fig. 1. Proximal signaling factors recruited to the SMAC. Several receptor-associated tyrosine kinases and adaptor proteins are recruited to the SMAC upon engagement of the antigen receptor complex. Key players are represented here. DAG is also generated through the action of PLC ${gamma}$ 1 and subsequently serves to activate PKC ${Theta}$ , which is the isoform of PKC that is specifically recruited to the SMAC in T cells.