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Fig. 2. Models of FGF1 (above) and IL-1{alpha} (below) stress-induced release pathways. I, Actin cytoskeleton-dependent transport of the release complex components. II, Cu2+-dependent formation of the release complex at the inner leaflet of the cell membrane. III, Association of the release complex with annexin II. IV, Phosphatidylserine-dependent flipping of the release complex through the cell membrane.