Fig. 1. Sequence variation in eIF4H between species. (A) Comparison of amino acid sequences for eIF4H in H. sapiens (accession number Q15056), D. melanogaster (accession number CG4429) and C. tentans (accession number AJ511864). The N-terminus, with its RNA-binding domain, and the C-terminus are similar in the three species. The largest variation is in the central part of the protein, where all proteins are rich in glycine residues. Conserved residues are highlighted: black indicates identical residues; grey indicates related residues. (B). The intron positions (indicated by the arrows) in eIF4H in H. sapiens, D. melanogaster and C. tentans are shown. Gaps (larger than two amino acid residues) have been introduced in the proteins in accordance with the alignment in Fig. 1A.