Fig. 10. Corneal epithelial defects after brushing the corneal surface with a microsponge. Wild-type (A,B) and SEY (+/–) (C,D) eyes from 6-week-old mice were untreated (A,C) or treated (B,D) by brushing the corneal surface with a microsponge. The eyes were then stained with fluorescein, washed and photographed. After brushing, intense, diffuse fluorescein staining was observed in the SEY (+/–) cornea (D), in contrast to that observed in the wild-type cornea (B). Abbreviation: c, cornea.