Fig. 8. Schematic view of steps in calmodulin redistribution under microtubule stabilising treatment with paclitaxel. The CaM initially remains associated with centrosomal matrix and kinetochore-to-pole microtubules, as in control cells. At the spindle pole the CaM-EGFP appears to subdivide from its ring-like shape, along with entire fragments of the spindle, including microtubules and associated kinetochores and chromosomes. Further repetition of this process generates a multipolar spindle, with CaM seen in a ring-like structure at each of these poles, some of which contain centrioles, and the chromosomal material becomes disorganised.