JCS -- Rudner et al. 114 (23): 4161 Figure IG4

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Fig. 4. Breakdown of the mitochondrial membrane potential after irradiation occurs prior to caspase activation. Prior to irradiation (10 Gy) cells were pretreated with the broad-spectrum caspase inhibitor zVAD (20 µM). No influence on the breakdown of ${Delta}$ ${Psi}$ _m was detectable (A), although caspase activation indicated by the abrogation of PARP cleavage was blocked (B).