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Fig. 3. Air-dried meiotic metaphase I (MI) chromosome spreads labeled with chromosome paint probes (2, green; 8, red). (A) MI from a B6 mouse displaying proper pairing of homologs.

(B) Homologous pairing in an MI spermatocyte from a Rb/+ male.

(C) Failure in homologous chromosome pairing in an MI spermatocyte from a Rb/+ mouse. Scale bar: 5 µm.