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Fig. 5. CHMP1 is a conserved member of a structurally related, but divergent, family of yeast and mammalian proteins. (A) The six yeast Chm proteins show related size and predicted isoelectric point (pI) values for their N- and C-terminal halves. Yeast CHM open reading frame assignments are CHM1, YKR035w; CHM2, YKL002w; CHM5, YDR486c; and CHM6, YMR077c. (B) Phylogenetic tree for proteins of the yeast Chmp (boxed) and human CHMP families is shown. ClustalX was used to construct the tree (Thompson et al., 1997). D is a measure of sequence divergence. GenBank accession numbers for human proteins are: CHMP1, AF281063; CHMP1.5, AF281064; CHMP2 (BC-2), AF042384; CHMP2.5 (CGI-84), AF151842; CHMP3 (NEDF), AF219226; CHMP4 (HSPC134), AF161483; CHMP5 (CGI-34), AF132968; and CHMP6, AW965590.