Fig. 1. Schematic representation of Hrs. The boundaries of the different domains are indicated by their corresponding amino acid numbers. Putative coiled-coil domains (CC1 and CC2) were identified with the Coils program (Lupas et al., 1991), whereas the VHS and FYVE domains were identified with SMART (Schultz et al., 1998). Domains rich in proline or proline and glutamine are indicated.